One of the most accepted hypotheses related to Alzheimer’s disease (AD) is the cascade of neuroinflammation, which is correlated with systemic inflammation and may be originated by immunosenescence, adipose tissue and/or intestinal imbalance. Therefore, there are several antioxidant and/or anti-inflammatory nutrients or food components with epigenetic properties, which can certainly help mitigate or delay the development of the disease. Inadequate dietary patterns can facilitate the development of the disease, while a healthier style, such as the Mediterranean diet, can exert positive effects. Understand all about Alzheimer’s disease and nutrition.
Nutrition in the management of Alzheimer’s disease
Studies show that the Mediterranean diet can help in the management of Alzheimer’s disease. Increased adhering to this dietary pattern may provide benefits to reduce the risk of cognitive problems, dementia in cognitively healthy people, and decreased progression of mild cognitive impairment to Alzheimer’s. The Mediterranean diet is an important source of nutrients, such as monounsaturated fatty acids, polyunsaturated fatty acids, micronutrients and antioxidants derived from the consumption of nuts, fruits, vegetables, vegetables, cereals and fish, with moderate intake of alcohol, red meats and dairy products, which confers considerable benefits, acting in the pathological processes involved in Alzheimer’s.
Just as feeding can help in the management of Alzheimer’s disease, inadequate feeding can favor progression. A low fat intake and high intake of processed carbohydrates instantly increases postprandial blood glucose levels. This condition disrupts serum proteins, favoring the formation of advanced glycation end products. They are highly induced by fructose consumption, commonly used by the food industry. In addition, they alter lipid homeostasis in the brain and permanently increase insulin/insulin-like growth factor signaling, affecting normal neuronal membrane function and integrity, including glucose transporters, promoting brain cell damage, followed by behavioral and cognitive changes.
Nutrients participate in the formation, physiological, anatomical, and maintenance of brain health. Several nutrients have been studied in the search for mechanisms triggered by alzheimer’s disease pathology. Feeding can help in the management of Alzheimer’s disease, and the Mediterranean diet is the most recommended dietary pattern.
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Alzheimer’s and nutrition
– Muñoz Fernández SS, Lima Ribeiro SM. Nutrition and Alzheimer’s Disease. Clin Geriatr Med. 2018;34(4):677-697. doi:10.1016/j.cger.2018.06.012